XBI
State Street SPDR S&P Biotech ETF
SPDR S&P Biotech ETF seeks to replicate the performance of the S&P Biotechnology Select Industry Index, an equal-weighed index. The Index tracks all the US common stocks listed on the NYSE, Ame
US
EQUITY
Rules-Based
MANAGEMENT STYLE
$ 7.8 B
ASSETS UNDER MGMT
35 bp
EXPENSES
Fund Basics
| Inception date | Jan 31, 2006 |
| Regulation | Open-Ended Fund |
| Fund Website | link... |
| Distributions | Quarterly |
| Currency | USD |
| Holdings Transparency | Full |
| Derivatives-based | No |
| Options available | Yes |
| Currency hedged | No |
| Fund of funds | No |
Top 10 Holdings
Complete list +
| TRAVERE THERAPEUTICS, INC. | 1.8 % |
| REVOLUTION MEDICINES, INC. | 1.8 % |
| ALKERMES PLC | 1.7 % |
| TWIST BIOSCIENCE CORP. | 1.6 % |
| TG THERAPEUTICS INC | 1.5 % |
| ARROWHEAD PHARMACEUTICALS, INC. | 1.5 % |
| BEAM THERAPEUTICS, INC. | 1.4 % |
| NEUROCRINE BIOSCIENCES INC | 1.4 % |
| KRYSTAL BIOTECH, INC. | 1.4 % |
| EXELIXIS INC | 1.4 % |
Constituent Breakdown
| Number of holdings | 136 |
| Herfindahl-Hirschman Index | 98 |
| Wgt avg mkt cap (mns) | $19,132 |
| Large cap (>$10bn) | 28.6% |
| Mid cap ($2-10bn) | 40.3% |
| Small cap (<$2bn) | 25.5% |
| Developed mkts. | 96.0% |
| Emerging mkts. | 0.0% |
Sector Breakdown
Country Exposure
 |
UNITED STATES | 91.8 % |
 |
IRELAND | 1.8 % |
 |
SWITZERLAND | 1.3 % |
 |
BRITAIN | 1.1 % |
 |
NETHERLANDS | 0.6 % |
Historical Performance
Standardized Performance (as of 05/31/2026)
| YTD | 1 YR | 2 YR | 3 YR | 5 YR | 10 YR | 20 YR | Incep. | |
|---|---|---|---|---|---|---|---|---|
| Price Returns | 12.1% | 72.6% | 23.8% | 17.7% | 1.3% | 8.9% | 11.7% | 11.0% |
| Dividend Yield | 0.0% | 0.6% | 0.3% | 0.2% | 0.1% | 0.2% | 0.3% | 0.3% |
| Total Returns | 12.1% | 73.2% | 24.2% | 17.9% | 1.4% | 9.1% | 12.0% | 11.3% | Ann. Volatility | 29.2% | 25.1% | 26.6% | 27.0% | 32.1% | 32.0% | 30.7% | 30.6% |
Market Correlations
| versus... | Beta | R-squared |
| S&P 500 | 1.15 | 29% |
| MSCI EAFE | 0.92 | 30% |
| MSCI Emg Mkts | 0.61 | 23% |
Liquidity Measures
| Avg. volume (000) | 8,398 |
| ADV traded (mns) | $1,073 |
| Turnover | 13.7% |
| Avg. Bid/Ask (% of price) | 0.01% |
Technical Indicators
| 30d moving avg. (EMA) | $132.67 |
| Relative strength (RSI) | 56 |
| MACD/Signal | 0.73/0.42 |
| Bollinger Bands (Upper/Lower) | $138.77/$127.82 |
| Short interest (% of AUM) | 112.5% |
Distributions
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Comparable ETFs Based on Overlap
| Ticker | Fund Name | Overlap vs. XBI |
Expenses vs. XBI |
ALTAR Score™ vs. XBI |
|---|---|---|---|---|
| IBB | iShares Biotechnology ETF | 41.3% | +10 bp | -0.5% |
| BBP | Virtus LifeSci Biotech Products ETF | 41.0% | +44 bp | -3.9% |
| BBC | Virtus LifeSci Biotech Clinical Trials ETF | 35.2% | +44 bp | +0.1% |
| WDNA | WisdomTree BioRevolution Fund | 34.9% | +10 bp | -2.9% |
| IBBQ | Invesco Nasdaq Biotechnology ETF | 33.8% | -16 bp | +0.4% |
| SBIO | ALPS Medical Breakthroughs ETF | 27.6% | +15 bp | +0.1% |
| GNMX | Corgi Genomics & Precision Medicine ETF | 26.3% | 0 bp | -4.2% |
| FTXH | First Trust Nasdaq Pharmaceuticals ETF | 25.8% | +25 bp | +7.8% |
| HELX | Franklin Genomic Advancements ETF | 23.6% | +15 bp | -0.9% |
| CANC | Tema Oncology ETF | 23.0% | +40 bp | -2.0% |
Risk and Returns: XBI vs. Comps (1 YR)
Notes: Top 10 overlapping ETFs. Funds with insufficient history not shown. Some funds may overlap. Hover over data point for ticker symbol.
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Results & Estimates (USD)
| 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | 2027 | ||
|---|---|---|---|---|---|---|---|---|---|
| Sales per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- | ||
| Earnings per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- | ||
| Dividends per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- | ||
| Book value per share | -- | -- | -- | -- | -- | -- | -- | ||
| change (%) | -- | -- | -- | -- | -- | -- | -- |
Return on Equity
Net Margins
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Valuation Metrics
| Fwd Est | 2025 | 2026 | 2027 | |
| Price-to-sales | --x | --x | --x | --x |
| Price-to-earnings | --x | --x | --x | --x |
| Price-to-cash flow | --x | --x | --x | --x |
| Price-to-growth | --x | --x | --x | --x |
| Price-to-book value | --x | --x | --x | --x |
| Yield | --% | --% | --x | --% |
Based on closing prices from 6/3/2026
Peer Group Comparison
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Historical Valuation Trends Sample data. Subscribe for access.
Notes: Based on adjusted historical results for current fund constituents. May differ from results achieved by past fund constituents. Max P/E of 100x.
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ETF Research Center Rating
-0.1%
ALTAR SCORE™
1st
PERCENTILE
AVOID
ETFRC RATING
There are 1,399 funds in the US Equity category with an average
ALTAR Score™ of 5.3% and a standard deviation
of 2.1%. XBI's ALTAR Score™ is approximately -2.5 standard
deviations above the category average. This places XBI in the 1st percentile
among funds in the category.
Sell-Side Consensus
$170
PRICE TARGET
+33.1%
UPSIDE